This blog looks at the pseudoscience twoodle by @GoodwinMJ and the implications of human genetics being a big complex family tree. It also looks at the rapid explosion of humans out of Africa and the mixing of humans since antiquity.
Ewan Birney
Deputy Director General of EMBL, Director of EMBL-EBI. I have an insatiable love of biology. @ewanbirney@genomic.social. I also work with ONT, Dovetail + GeL.
The hypothesis is that most ageing changes are not a result of a build-up of molecular damage but are rather a product of regulated processes. This thread explores the idea that the genome is a developmental program encoded in the DNA sequence, and how ageing can be seen as a software design flaw.
João Pedro de Magalhães
Scientist planning to live forever (so far so good!), professor decoding the genome @unibirmingham, big data, geek, consultant, speaker, keen footballer.
Learn about a method to explicitly model how cytosine modifications on one side of a base pair or the other might affect transcription factor binding. Understand how to expand the alphabet and develop a model to understand the effects.
Michael Hoffman @michaelhoffman@mastodon.social
Computational genomicist, Princess Margaret Cancer Centre. Assoc Prof, Medical Biophysics & Computer Science, University of Toronto. COI https://t.co/CvupKNIjZr
This paper on @biorxivpreprint explores how misactivation of developmental enhancers for the SOX2 transcription factor leads to overexpression in breast and lung cancer. Learn about the promoter, potential enhancers, and more.
Michael Hoffman @michaelhoffman@mastodon.social
Computational genomicist, Princess Margaret Cancer Centre. Assoc Prof, Medical Biophysics & Computer Science, University of Toronto. COI https://t.co/CvupKNIjZr
The third human genome editing summit has finished and it was a mix of science, ethics, law and patients. An informed genomics expert shares their thoughts on the summit, including the distinction between germline editing and implanting an embryo.
Ewan Birney
Deputy Director General of EMBL, Director of EMBL-EBI. I have an insatiable love of biology. @ewanbirney@genomic.social. I also work with ONT, Dovetail + GeL.
What is genome editing? Learn about this technology, which was created by the discovery and exploitation of a bacterial anti-virus immune system, and its implications for the future of medicine.
Ewan Birney
Deputy Director General of EMBL, Director of EMBL-EBI. I have an insatiable love of biology. @ewanbirney@genomic.social. I also work with ONT, Dovetail + GeL.