Healthy Aging: The Comparator Group
One of the most important things to keep in mind about healthy aging is the comparator group. Lean humans that don't eat super late are already time-restricted and are unlikely to get benefits from more dietary rules.
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Charles Brenner, PhD
Discovered NR as an NAD precursor vitamin Dept Chair @CityofHope Chief Scientific Advisor @ChromaDex No BS zone Tweets are mine alone
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one of the most important things to keep in mind about healthy aging is the comparator group
— Charles Brenner, PhD (@CharlesMBrenner) April 13, 2023
if the control group is ad libitum fed, the dietary restricted group will be healthier
if you're a lean human, you cannot assume you will be healthier with dietary restriction -
time restricted feeding clearly shows better fitness than ad lib for animals that eat all the time
— Charles Brenner, PhD (@CharlesMBrenner) April 13, 2023
but lean humans that don't eat super late already are time-restricted and are unlikely to get benefits from more dietary rules -
bc many humans have anxiety about aging, it's easy for researchers to extrapolate from a worm, fly or mouse result to make recommendations based on these mechanisms--you do not want to be on the receiving end of hype
— Charles Brenner, PhD (@CharlesMBrenner) April 13, 2023 -
in the human context, calorie deficit essentially produces wt loss. this will be beneficial for some but not ppl who are already lean
— Charles Brenner, PhD (@CharlesMBrenner) April 13, 2023 -
protein restriction & mTOR inhibition don't make a ton of sense to me either as general strategies for healthy aging--you really want to maintain skeletal muscle mass & function. i really don't think that ppl want to age like growth hormone-deficient animals
— Charles Brenner, PhD (@CharlesMBrenner) April 13, 2023 -
i do think there's a role for NR to promote resiliency as we age but the thing to remember is that there is no magical hack
— Charles Brenner, PhD (@CharlesMBrenner) April 13, 2023
maintain high physical & mental activity & social engagement, eat well & not too much, avoid nonprescribed drugs & alcohol, don't smoke, avoid violence
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