Cerebrolysin: A Drug to Halt/Reverse CTE and Alzheimer's

What if I told you there were a drug that could halt/reverse CTE and Alzheimer's?

What if I told you that drug could reverse stroke damage?

Cerebrolysin is that

Thread below

👇 pic.twitter.com/03oFTVerPS

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Quick disclaimer

This is educational only. I am not making any recommendations

Do not ask me how to get it or how much to take

This will also be a BRIEF summary as this thread will be long enough as is

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Cerebrolysin is a neuropeptide that improves the brain's ability for self-repair by stimulating neuro recovery.

It has numerous pharmacological effects, which will be listed below

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Pharmacological effects:

- Protection against excitotoxicity

- Reduction of free radicals

- Reduction of pro-apoptotic enzymes

- Modulation of inflammatory effect

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Pharmacological effects cont.

- Improvement of BBB integrity

- Neuroplasticity

- Neurogenesis

- Reduction of post stroke dementia

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Protection against excitotoxicity

-Overstimulation by L-glutamate damages neurons

-Cerebrolysin inhibits this

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Reduction of free radicals

-Free radicals are involved heavily in Alzheimer's and strokes

-Cerebrolysin is shown to greatly reduce the formation of free radicals following an ischemic event

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Reduction of pro-apoptotic enzymes

-Apoptosis is cell death

-Cerebrolysin reduces the number of neurons capable of this

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Modulation of inflammatory effect

-Blood clots that lead to stroke cause the endothelial cells to become inflammatory

-Cerebrolysin reduces the cytokine storm that causes this

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Improvement of BBB integrity

-The blood brain barrier is damaged by fibrin deposits and loses permeability

-Cerebrolysin improves the BBB by promoting vascular integrity via Ang1, VEGF, and SHH

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Ang1 (angiopoietin 1) promotes blood vessel remodeling and maturation

VEGF (vascular endothelial growth factor) promotes blood vessel formation

They both do a bit of each but this is good enough of a generalization for now

SHH will be addressed a bit further down

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Improves Neuroplasticity

-Neuroplasticity is simply the ability of the brain to rewire itself in response to new demand

-Cerebrolysin increases the number of new synapses

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Neurogenesis

-Ischemic strokes cause neurons to deteriorate as well as blood vessel atrophy

-Cerebrolysin stimulates neurovascular growth and repair

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Reduction of post stroke dementia

-After a stroke, the blood clot breaks up and can lead to mini clots downstream in smaller vessels, continuing the release of cytokines

-Cerebrolysin restores normal blood flow through the mechanisms mentioned above

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Cerebrolysin modifies two major signaling pathways:

1. The neurotrophic factor (NTF)

2. Sonic hedgehog (SHH) signaling pathways

These both maintain and repair the neuronal network

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Neurotrophic factor:

-Maintain, protect and restore neural network

-Ensure proper brain function

-Survival and regeneration of the neuronal
network

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

Sonic hedgehog signaling pathways:

-Regulates the development of organs including the organization of the brain

-Amplifies recovery of neurons

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023

I say all of this to sum up as follows:

Cerebrolysin improves the ability of the brain to recover by stimulating neuro recovery across many pathways

— BowTied Kobra, Rehab Guy (@bowtiedkobra) March 2, 2023